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Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer
Galindo Moreno, María; Giráldez Macías, Servando; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Nature Publishing Group, 2017)Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic ...
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Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway
Belmonte Fernández, Alejandro; Herrero Ruiz, Joaquín; Galindo Moreno, María; Limón Mortés, María Cristina; Mora Santos, María del Mar; Sáez, Carmen; Japón, Miguel A.; Tortolero García, María Dolores; Romero Portillo, Francisco (Springer Nature, 2023)Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment ...
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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
Luna Varo, Rosa María; Japón Rodríguez, Miguel Ángel; Sáez, Carmen; Domínguez Sánchez, María Salud; Aguilera López, Andrés (2011)One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells
Gasca, Jessica; Flores, María Luz; Jiménez Guerrero, Rocío; Sáez, M. E.; Barragán, Isabel; Ruíz Borrego, Manuel; Tortolero García, María Dolores; Romero Portillo, Francisco; Sáez, Carmen; Japón, Miguel Á. (Springer Nature, 2020)Epithelial–mesenchymal transition (EMT) has recently been associated with tumor progression, metastasis, and chemotherapy ...
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Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.
Mora Santos, María del Mar; Limón Mortés, María Cristina; Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (The American Society for Biochemistry and Molecular Biology, 2011)PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during ...
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HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients
Hontecillas Prieto, Lourdes; García-Domínguez, Daniel J.; García Mejías, Rosa; Ramírez Villar, Gema; Sáez, Carmen; Álava Casado, Enrique de (Impact Journals, 2017)Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT ...
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Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer
Gasca, Jessica; Flores de Mera, María de la Luz; Giraldez Macias, Servando; Tortolero García, María Dolores; Ruiz-Borrego, Manuel; Romero Portillo, Francisco; Japón, Miguel A.; Sáez, Carmen (Impact Journals, 2016)FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins ...
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p53 and FBXW7: Sometimes Two Guardians Are Worse than One
Galindo Moreno, María; Giráldez Macías, Servando; Limón Mortés, María Cristina; Belmonte Fernández, Alejandro; Sáez, Carmen; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (MDPI, 2020)Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute ...
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Securin Is a Target of the UV Response Pathway in Mammalian Cells
Romero Portillo, Francisco; Gil-Bernabé, Ana M.; Sáez, Carmen; Pintor Toro, José Antonio; Tortolero García, María Dolores (2004)All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing ...